As the global salmon farming industry enters a critical stage of high-quality and green development, innovative feed additives have become key to breaking through production bottlenecks. Leveraging its profound expertise in microbial fermentation, Angel Yeast proudly launches yeast nucleotide products NT20/NT40, with nucleotide content ≥20% and ≥40% respectively. Using natural bioactive ingredients, these products precisely address core challenges in salmon farming, including intestinal damage, immunosuppression, and weak stress resilience. Backed by data from the authoritative academic study Yeast nucleotide enhances barrier function by regulating the intestinal microbiota and metabolic pathways of fish to alleviate virus-induced intestinal damage, co-authored by Angel Yeast, these products deliver outstanding benefits: strengthened intestinal barrier, enhanced immunity and stress resistance, and improved growth performance, providing a new solution for efficient and healthy salmon farming worldwide.

1. Protecting the Intestinal Barrier: Building a Solid Defense for Salmon Health
The intestine is the core organ for nutrient absorption and immune defense in salmon. Viral invasion and environmental stress often damage the intestinal mucosa and disrupt microbial balance, directly restricting farming efficiency.
1.1 Repair Intestinal Damage and Strengthen Barrier Function
They significantly upregulate the expression of the tight junction protein Occludin, greatly improving intestinal barrier integrity and blocking viral entry via the gut. They also accelerate the repair of virus-induced intestinal mucosal damage, resulting in significantly higher intestinal fold height, mucosal thickness, and structural integrity compared to the control group.

Figure 1 Effects of yeast nucleotides on intestinal structure and morphology in salmon

1.2 Regulate Microbial Balance and Optimize Intestinal Microbiota

Figure 2 Regulation of yeast nucleotides on the intestinal microbial community structure in salmon

They selectively shape the intestinal microbial community by significantly increasing the abundance of beneficial bacteria including Romboutsia, Bacillus, Turicibacter, and Clostridium sensu stricto 1, while inhibiting pathogen colonization. This stabilizes the intestinal microenvironment and reduces the incidence of enteritis, diarrhea, and other digestive disorders. A healthy intestine drastically improves nutrient digestion and absorption, laying a solid foundation for faster growth and stronger fitness.

2. Activating Immune Potential: Enhancing Stress Resistance across the Board
During the salmon farming cycle, stressors such as seawater transfer, handling, and pathogenic infection frequently cause immunosuppression, leading to high disease rates and mortality.
As a natural immunostimulant, Angel Yeast NT20/NT40 deeply activates both nonspecific and specific immunity in salmon:

(1) Boosts the activity of immune factors including lysozyme and peroxidase, strengthens macrophage phagocytosis, and rapidly eliminates invasive pathogens;

(2) Enhances mucosal immunity and suppresses excessive inflammation by regulating the NF-κB p65 signaling pathway, markedly improving antiviral capacity;
In challenge trials with Infectious Hematopoietic Necrosis Virus (IHNV), the 500 mg/kg nucleotide group showed significantly lower cumulative mortality than the control. Intestinal mucus from nucleotide supplemented fish also exhibited direct antiviral activity against IHNV, demonstrating strong disease protection.

Figure 3 Effects of yeast nucleotides on survival rate of salmon against IHNV infection
Meanwhile, yeast nucleotides effectively alleviate stress from seawater transfer and highdensity rearing, maintain physiological homeostasis, and significantly improve survival rate and population uniformity.

3. Optimizing Growth and Metabolism: Boosting Quality and Efficiency for Industrial Upgrading
Supported by Angel Yeast’s collaborative research and multiple international publications, supplementing salmon feeds with NT20/NT40 achieves simultaneous improvements in growth performance and economic returns.
3.1 Accelerate Growth and Improve Feed Conversion
At 500 mg/kg, coho salmon achieved the highest specific growth rate among all treatments, along with improved feed efficiency and protein deposition, delivering faster growth and lower FCR. By supporting energy metabolism and protein synthesis, yeast nucleotides enhance nutrient utilization and shorten the culture cycle.

Figure 4 Effects of yeast nucleotides on growth performance and feed efficiency in salmon

3.2 Improve Body Quality and Economic Value
By modulating lipid metabolic pathways and enhancing bioactive metabolite levels, yeast nucleotides reduce muscle fat deposition, increase muscle protein content, and enhance flesh quality and nutritional value, matching demands of the highend consumer market.
3.3 Enhance Antioxidant Status and Salinity Adaptation
They significantly improve hepatic antioxidant indicators by reducing malondialdehyde (MDA) and lowering oxidative damage. They also strengthen osmoregulatory capacity, supporting smooth freshwatertoseawater transfer and reducing growth stunting caused by handling stress.

Figure 5 Effects of yeast nucleotides on antioxidant capacity in salmon liver

4. Angel Yeast NT20/NT40: Natural and Safe, Aligned with Global Green Aquaculture Trends
Produced from food-grade yeast using patented bio-extraction processes, Angel Yeast NT20/NT40 contains no antibiotics, hormones, or residues, complying with global green aquaculture standards and meeting strict requirements for export grade salmon production.
By integrating nutritional supplementation, immune regulation, and intestinal repair, these products effectively replace conventional feed additives, supporting the industry shift from “disease control via chemicals” to “disease prevention via nutrition” and promoting sustainable, high quality development.
From laboratory research to commercial farming, Angel Yeast continues to empower aquaculture through biotechnology. Backed by scientifically validated performance, yeast nucleotide products NT20/NT40 have become essential functional additives in salmon farming. Going forward, Angel Yeast will keep innovating in aquatic nutrition, providing higher quality products and professional technical services to partner with global producers, build a new ecology for healthy salmon farming, and unlock new momentum for blue economic growth.

References
1.Angel Yeast Co-author Paper. Yeast nucleotide enhances barrier function by regulating the intestinal microbiota and metabolic pathways of fish to alleviate virus-induced intestinal damage.
2.Burrells C, Williams PD, Southgate PJ, Wadsworth SL. 2001. Dietary nucleotides: a novel supplement in fish feeds 2. Effects on vaccination, salt water transfer, growth rate and physiology of Atlantic salmon. Aquaculture, 199: 171-184.
3.Li P, Gatlin DM III. 2006. Nucleotide nutrition in fish: current knowledge and future applications. Aquaculture, 251: 141-152.
4.Hunt AÖ, Özkan-Yılmaz F, Engin K, et al. 2016. Effects of Dietary Nucleotide Yeast on Immune Responses and Antioxidant Enzyme Activities of Rainbow Trout Juveniles. Israeli Journal of Aquaculture - Bamidgeh, 68.

About Angel Animal Nutrition

Angel Animal Nutrition focuses on providing professional yeast solutions for animal nutrition, caring for animal health, reducing antibiotic use, and promoting the sustainable development of the livestock industry. Together with our partners, we are always in action, working hand in hand to create a better future.

About Angel

Angel Yeast Company is a high-tech listed company specializing in yeast and biotech. Product business covers Yeast and Baking, Yeast Extract-Savoury, Nutrition & Health and Biotechnology fields. It is one of the world's leading companies in the yeast industry. Angel has 12 holding subsidiaries and provides products and services for more than 150 countries and regions.

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