Have you ever envied those who can eat whatever they want without gaining weight? Don't worry, yeast might have the answer. Recent research suggests that yeast protein could be the secret weapon behind their slim figures. Let's explore how yeast protein can awaken the "slim microbiota" within your body.

Gut Health: A Crucial Factor in Obesity

The gut is not just where we digest and absorb food; it's also a complex microbial ecosystem. The microbial community in the gut, especially the gut microbiota, has a profound impact on our health. The composition of the gut microbiota can affect weight loss and fat accumulation. Human studies have linked gut microbiota imbalances with obesity and metabolic diseases^[1,2]. Generally, obese individuals show decreased bacterial diversity and gene richness, with an increased abundance of Firmicutes and a decreased abundance of Bacteroidetes^[3]. These findings suggest a complex interaction between gut microbiota and obesity, where specific gut bacteria may influence the host's metabolic health and body weight through various mechanisms.

Bacteroides Thetaiotaomicron: The Gut's Anti-Obesity Warrior

Imagine your gut as a bustling community filled with diverse bacteria. Among them, Bacteroides thetaiotaomicron is one of the few "good neighbors" that help keep you slim. However, in obese individuals, these bacteria tend to be less active. Fortunately, yeast protein acts like a superhero in the gut, significantly increasing the abundance of these "good neighbors" and revitalizing them.

As early as 2017, studies^[4] have been reported that intragastric administration of active Bacteroides thetaiotaomicron could significantly reduce total fat mass and inguinal fat in mice. It also alleviated weight gain and obesity in mice fed a high-fat diet. Further mechanistic studies revealed that the role of Bacteroides thetaiotaomicron extends beyond directly influencing fat accumulation. It works by increasing the concentration of adiponectin in the plasma of mice. Adiponectin is a protein hormone secreted by fat cells that plays a crucial role in regulating blood sugar levels, promoting fatty acid oxidation, and reducing inflammation, all of which help boost energy metabolism and combat obesity.

Fig.1 Effects of PBS (blank control group), KBT (inactivated Bacteroides polymorpha) and LBT (active Bacteroides polymorpha)

on body composition of mice by gavage

Yeast Protein: Your New Weight Loss Ally

Yeast protein is a nutrient-rich food ingredient that has been extensively researched and used in various health applications. The latest research from Angel Yeast suggests that yeast protein can not only provide the amino acids needed by the human body, but also may have a positive impact on regulating the balance of intestinal microbial communities, especially increasing the abundance of Bacteroides thetaiotaomicron. The study found that after consuming three different proteins, the number of Bacteroides thetaiotaomicron cells in the yeast protein group significantly increased from a relatively low level (5.0e+07 cells/mL) to 1.5e+08 cells/mL.

This increase indicates that yeast protein intake may help boost the proportion of beneficial bacteria in the gut, thereby improving gut health and overall metabolic. By increasing the abundance of Bacteroides thetaiotaomicron, yeast protein may help improve the body's metabolic efficiency and have a positive impact on weight management.

Fig.2 (A) The Impact of Three Different Proteins on Gut Microbiota Abundance

(B) The Effect of Three Different Proteins on the Abundance of Bacteroides thetaiotaomicron Compared to the Blank Control Group (NSC)

In the pursuit of healthy weight loss, we often seek solutions that offer long-term benefits. Yeast protein is one such option, as it promotes gut health and helps our bodies manage energy metabolism and fat more effectively. This natural and scientifically supported approach provides a gentle yet lasting method for weight management.

References

[1] Karlsson, F.H. et al. Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature 498, 99-103 (2013).

[2] Qin, J. et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 490, 55-60 (2012).

[3] Ley, R.E., Turnbaugh, P.J., Klein, S. & Gordon, J.I. Microbial ecology: human gut microbes associated with obesity. Nature 444, 1022-1023 (2006).

[4] Ruixin Liu, Jie Hong, Xiaoqiang Xu, et al. Gut microbiome and serum metabolome alterations in obesity and after weight-loss interbention. Nature medicine, 23, 859-868 (2017).

About Angel Human Health：

Specialized in yeast and fermentation, AHH is committed to developing innovative, differentiated, science-based functional ingredients and customized solutions, to help our customers get enduring success, as well as contribute to a healthier and sustainable world together.

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Angel Yeast Company is a high-tech listed company specializing in yeast and biotech. Product business covers Yeast and Baking, Yeast Extract-Savoury, Nutrition & Health and Biotechnology fields. It is one of the world's leading companies in the yeast industry. Angel has 12 holding subsidiaries and provides products and services for more than 150 countries and regions.

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