History of S-boulardii
In 1920s, French microbiologist, Henri Boulard was in IndoChina searching for new strains of yeast that could be used in fermenting processes. He was a visitor during a cholera outbreak and he noticed that only the people who were drinking certain tea did not infect cholera.
The tea was made from the peel of tropical fruits (Lychee and Mangosteen), it succeeded in isolating the component (yeast) that is effective against diarrhea. The yeast was later named Saccharomyces boulardii by Dr. Boulard.
Since the isolation of the strain, extensive research has been conducted and more than 400 relevant studies have been published so far.In 1962, the strain began to be used for the treatment of human diarrhea (as a prescription drug), Long used for over 50 years in certain medicines and now available in dietary supplements form. S-boulardii has been used in more than 80 countries all over the world.
Most successful probiotics in clinical trials
Among the results of meta-analysis of 273 clinical trials for various probiotics, S-boulardii is in the top 3 clinical trials, the success rate of clinical trials of other probiotics is around 50%, while S-boulardii has a high success rate of 80%.
Meta-analysis of 273 clinical trials for probiotics
Effective on Antibiotic-associated diarrhea
AAD (Antibiotic-Associated Diarrhea) is observed as a side effect in approximately 20% of patients who receive antibiotic treatment.
Antibiotics act on not only pathogenic bacteria but also all bacteria in the intestine and kill good bacteria, so the balance between the good bacteria and bad bacteria will be damaged (the main cause of AAD is Clostridium difficile overgrowth and toxins produced by it ).
Because S-boulardii is not bacteria but yeast, it is less influenced by antibiotics, and it has been reported that the incidence of diarrhea is significantly reduced when S-boulardii is combined comparing to taking antibiotics alone.
Effect of S.boulardii on antibiotic-associated diarrhea
Highlights of Angel S-boulardii
-Strain identification: proprietary strain
-Identified with genetics techniques
-Human clinical study ongoing: anti-diarrhoea
-Patented strain preservation CCTCC M2012116
-Product and production process patents: 201210131832.8
-Proven survival through the gastric system
-24 months stability at room temperature, vacuum packing
-World leading profesional yeast supplier
Functions & Benefits
1. Anti-diarrhea, including:
-Diarrhoea due to clostridium difficile infection (CDI)
-Acute diarrhea & Persistent diarrhea
2. Comfort intestinal & improving intestinal flora
3. Stimulation of intestinal immune response
Stable in room temperature
Unlike other probiotics, S-boulardii is highly stable and there is no need for refrigerated storage, making it ideal as a supplement for those with diarrhea and constipation during travel.
Stability Of Angel S.Boulardii
S-boulardii can be easily applied in capsules, sticks or sachet. General daily dosage is 250 mg (equivalent to 5 billion colony-forming units per gram) to be taken while travelling or when starting the antibiotic treatment and continuing for a few days after antibiotics are stopped.