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Using Biological Antibacterial Agents to Control Microbial Pollution in Alcohol Production Process

Published by Hui Li, edited by George Hu.

31st December, 2023.

The fermentation process of alcohol is a complex reaction of microorganisms. In addition to the yeast that plays a fermentation role, a considerable amount of miscellaneous bacteria are also brought in from raw materials, air, water, pipelines, dead corners of equipment, etc. Therefore, alcohol fermentation is not a strictly sterile process. During the entire alcohol fermentation process, a small amount of miscellaneous bacteria will not affect the overall fermentation. However, if measures are not taken to control it, the miscellaneous bacteria will multiply in large numbers, consuming a large amount of carbon, nitrogen, amino acids and other substances, reducing yeast growth rate and biomass, ultimately causing the mash to sour and have a significant impact on the normal production and yield of alcohol. Therefore, effective control of miscellaneous bacteria in the production process is an important factor affecting the completeness of alcohol fermentation.


There are two main types of miscellaneous bacteria commonly found in alcohol production: bacteria and wild yeast. Bacteria and other miscellaneous bacteria pose the greatest threat to alcohol fermentation. Bacteria can be divided into Gram positive bacteria and Gram negative bacteria. Gram positive bacteria include Lactobacillus, Staphylococcus (Staphylococcus), Leuconostoc, Butyracillus, and Bacillus subtilis; Gram negative bacteria include Acetobacter and Escherichia coli. Wild yeast mainly includes Candida and Saccharomyces.


In order to reduce bacterial contamination during the fermentation process of the alcohol industry, acid treatment, the addition of antibiotics or chemical fungicides, etc. are generally used. However, there may be problems such as equipment corrosion, susceptibility to drug resistance, residual antibiotics and harmful chemicals. Therefore, developing natural antibacterial agents with strong antibacterial properties, no drug resistance, no residue, safety, and no toxicity is the future development direction.


Angel Yeast has developed a biological antibacterial agent by selectively enzymatic extraction of antibacterial polysaccharide components - glucan and mannan - from yeast cells. Its main functions are threefold. Firstly, it acts on the glycoprotein receptors of bacterial cell walls, interfering with normal metabolism and growth and reproduction of bacteria; The second is to destroy the cell wall or cytoplasmic membrane of bacteria, causing damage to the cell membrane, leading to the dissolution and extravasation of intracellular substances (proteins, inorganic ions, etc.), which in turn leads to bacterial cell death; Thirdly, it can also activate cell wall degrading enzymes (such as glucanase and chitinase), causing cell wall damage and exerting antibacterial effects. This product has a broad-spectrum antibacterial effect and has a significant inhibitory effect on Bacillus, Escherichia coli, Acetobacter, Staphylococcus aureus, etc. The product is safe, residue free, and drug resistant during use. This product is suitable for long-term use and can effectively inhibit the fermentation system's acid rise without affecting yeast growth and alcohol fermentation.

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About Angel Fermented Beverages

Angel brewing focus on the brewing microbial resource industrialization and its industrialized application including global distilling spirit, wine, fermented condiment and global biofuel. The team of angel brewing experts provides brewing microbial products and fermentation solutions to global customers.

About Distilled Spirits and Biofuels Division

Angel can provide brewing yeasts, ingredients and related technical services for the production of wine, beer, whisky, and other brewing liquor. All our products are natural, safe, and of high quality. With the current energy shortages around the world, the production of fuel ethanol through yeast fermentation has become an inevitable trend.

About Angel

Angel Yeast Company is a high-tech listed company specializing in yeast and biotech. Product business covers Yeast and Baking, Yeast Extract-Savoury, Nutrition & Health and Biotechnology fields. It is one of the world's leading companies in the yeast industry. Angel has 12 holding subsidiaries and provides products and services for more than 150 countries and regions.

For more media information, please contact

Angel Yeast Co., Ltd.

Yichang, Hubei, China

Ryan Wu

Tel.: +86 717 6353619

Email: niangzao@angelyeast.com


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