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How Yeast Protein Hydrolysates Promote Cell Growth and Improve the Stability and Sustainability of Cell Culture

Yeast protein hydrolysates, derived from yeast, constitute a nutritionally rich product containing polysaccharides, amino acids, peptides, vitamins, and trace elements. In recent years, these hydrolysates have found applications in mammalian cell culture for the production of antibodies, recombinant protein drugs, vaccines, and other fields. As effective additives supporting cell growth, product expression, and virus amplification, yeast protein hydrolysates exhibit broad application prospects and market potential.

In the field of animal cell culture, Angel has independently developed various production processes, resulting in a range of yeast protein hydrolysates with diverse nutritional characteristics. These hydrolysates are suitable for different cell culture scenarios based on specific requirements. Through extensive experimental validation and customer feedback, Angel's CM03, YI02, CM05, CM06, CM07, CM08, and CM09 have demonstrated significant advantages and potential in the field of cell culture.

Angel CM03 is a small-peptide-enriched hydrolysate with low osmotic pressure, applicable to various cell lines such as BHK21, SF9, HF, MDCK, HEK293, and possesses a certain degree of universality.

Angel YI02 is a hydrolysate produced through a special process, rich in growth factors and metal elements, suitable for cell lines like BHK21, MDCK, SF9, HF, and others.

Angel CM05 is an amino acid-enriched hydrolysate, exhibiting a significant effect in promoting cell growth in insect cell lines.

Angel CM07 is a glutathione-enriched hydrolysate with a glutathione content exceeding 10%, promoting cell growth and enhancing metabolic activity in cell culture. When applied to SF9 cell culture, CM07 significantly promotes cell growth, exhibits good cell passaging stability, virus sensitivity, and leads to higher protein expression levels.

Extensive experiments support the notion that amino acids and peptides in Angel's yeast hydrolysates provide the necessary nutrients for cell growth and proliferation, thereby promoting cellular growth and proliferation. The growth factors and cytokines in yeast hydrolysates activate cellular metabolic pathways, enhancing cell metabolic activity and product expression levels. Additionally, yeast hydrolysates can regulate the pH and osmotic pressure of the cell culture environment, improving the stability and sustainability of cell culture.


Published by Yinglei Chen
Assistant Engineer of Institute of Microbiology

About Angel Fermentation Nutrients

Angel Fermentation Nutrients, rich in protein, amino acids, peptides, nucleotides, B vitamins, and trace elements. With the advantages of having no allergic source and being non-transgenic, high efficiency, and stable quality, Angel YE are widely applied in biological laboratories and industrial-scale fermentation, promoting product safety and technical progress in the global fermentation industry.

About Angel:

Angel Yeast Company is a high-tech listed company specializing in yeast and biotech. Product business covers Yeast and Baking, Yeast Extract-Savoury, Nutrition & Health and Biotechnology fields. It is one of the world's leading companies in the yeast industry. Angel has 12 holding subsidiaries and provides products and services for more than 160 countries and regions.

Press contact:

Address: 168 Chengdong Avenue, Yichang, Hubei 443003, P. R.China
Tel: +86-717-6369227
Fax: +86-717-6368757
email: tangshuo@angelyeast.com
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