March 22, 2025
By Yongzhi Ding
Yeast extract is a nutrient-rich complex derived from cultured yeast through hydrolysis, containing peptides, amino acids, mineral ions, vitamins, and other functional factors. By utilizing specific yeast strains, targeted hydrolysis technology, and nutrient fractionation techniques, nutrient-enriched yeast extracts can be produced.
Challenges in Industrial Microbial Fermentation
E. coli, Corynebacterium glutamicum, and Bacillus spp. are widely adopted as chassis cells in industrial microbial fermentation. A critical challenge in large-scale fermentation arises from the inoculation volume limitation (typically 0.1%-1% v/v), primarily driven by the scale-up discrepancy between laboratory-prepared inoculum and industrial-scale bioreactors. This suboptimal inoculation level may induce extended lag phases due to metabolic reprogramming, suboptimal initial biomass density, and elevated contamination susceptibility during the vulnerable early fermentation phase. Notably, modern fermentation processes have established multiple mitigation strategies, including optimized media composition, fed-batch supplementation, and environmental control protocols.
To address this, Angel Yeast has developed nutrient-enriched yeast extracts that significantly enhance the growth rates of E. coli, Corynebacterium glutamicum, and Bacillus, thereby shortening cultivation cycles.
Product Highlights
1. Yeast Extract FM509-S
· A balanced peptide-rich yeast extract.
· Tested on E. coli BL21, it shortens the lag phase and accelerates the specific growth rate during the exponential phase compared to standard yeast extracts.
· Ideal for E. coli-based fermentation projects, including enzyme production, antimicrobial peptides, and amino acids.
Figure 1. Growth Curves of E. coli BL21 Cultured with Different Yeast Extracts
Key Features:
· Balanced peptide content promotes E. coli growth.
· Certified for food-grade and pharmaceutical-grade production.
2. Yeast Extract FM308-S
· A nutrient factor-enriched yeast extract.
· Tested on Corynebacterium glutamicum and Bacillus licheniformis, it reduces the lag phase and enhances the exponential growth rate.
Figure 2. a-Bacillus licheniformis (Industrial Chassis Strain)
Figure 3. b-Corynebacterium glutamicum (Industrial Chassis Strain)
Key Features:
· Rich and balanced nutrients improve the growth rates of Corynebacterium glutamicum and Bacillus.
· Certified for food-grade and pharmaceutical-grade production.
3. Yeast Extract FM308
· A cost-effective yeast extract enriched with small peptides and functional factors.
· Demonstrates superior growth-promoting effects on Bacillus subtilis, Bacillus licheniformis, Bacillus megaterium, and Bacillus amyloliquefaciens compared to standard yeast extracts.
· Recommended for Bacillus cultivation in bio-agriculture applications.
Figure 4. a-Bacillus megaterium (Wild Type)
Figure 5. b-Bacillus subtilis (Wild Type)
Figure 6. c-Bacillus licheniformis (Wild Type)
Figure 7. d-Bacillus amyloliquefaciens (Wild Type)
Key Features:
l Rich in small peptides and functional factors, ideal for Bacillus cultivation and growth enhancement.
l High cost-performance ratio.
Angel Yeast’s nutrient-enriched yeast extracts are designed to optimize microbial growth, reduce production timelines, and enhance fermentation efficiency, supporting a wide range of industrial and agricultural applications.
About Angel Fermentation Nutrients：
Angel Fermentation Nutrients, rich in protein, amino acids, peptides, nucleotides, B vitamins, and trace elements. With the advantages of having no allergic source and being non-transgenic, high efficiency, and stable quality, Angel YE are widely applied in biological laboratories and industrial-scale fermentation, promoting product safety and technical progress in the global fermentation industry.
About Angel:
Angel Yeast Company is a high-tech listed company specializing in yeast and biotech. Product business covers Yeast and Baking, Yeast Extract-Savoury, Nutrition & Health and Biotechnology fields. It is one of the world's leading companies in the yeast industry. Angel has 12 holding subsidiaries and provides products and services for more than 160 countries and regions.
Press contact:
email: tangshuo@angelyeast.com
