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Serum substitution—Angel Yeast launched new yeast extract for cell culture industry

December 14, 2019

By Yinqiang

Since 1955 and 1959, Dr. Harry Eagle has published research articles on cell culture formulations intwice and pointed out that cell culture media is "a kind of mixtures containing inorganic salts, amino acids, sugars, vitamins, and other essential nutrients with equal osmotic pressure and pH buffering capacity", which gave birth to the world's first and widely used "MEM" (Minimal Essential Medium) medium. This is the first milestone in the history of mammalian cell culture.

But as the defects of the serum-containing medium used in cell culture gradually appeared, the serum-free culture technology of animal cells attracted great attention. The conference "Improving in vitro culture methods and reducing fetal bovine serum use" held in April 2003 called for reducing serum use worldwide. For more than ten years, serum-free cell culture media has been in the development of vaccines, antibodies and recombinant protein drugs. Many fields such as production, cell & gene therapy, pharmacology and basic medical research (primary cell culture) have been widely used.

In recent years, a number of blockbuster targeted drugs such as Rituxan, Herceptin, Remicade, Enbrel, Humira, and Avastin have been developed and marketed in succession, which brings the gospel to patients and even boost the development of the application on cell culture technology in biopharmaceutical industry. More and more genes and immunotherapy have been approved for clinical trials, thus serum-free media has become the main cell culture media for antibody and recombinant protein production. In the cell culture process, including 293 cell and immune cell cultures, the need for a medium that does not contain animal sources (including human blood sources) and does not contain uncertain components is increasingly urgent. More importantly, the effects of animal-derived components, natural cytokines and growth factors on the immune cells in the culture medium have also been valued by the industry.

Under the background of frequent outbreaks of bird flu and African swine fever, for response to the trend of "healthier and safer meat" and "burden relief for the earth", the global "artificial meat" trend is coming and "artificial meat" products step onto the table of the consumers and will become one of our daily food ingredients. The vegetarian "plant meat" based on the concept of environmental protection came into the market, meanwhile the intensive industrialized farming and breeding were very inefficient and caused serious pollution, which also damaged the relationship between humans and animals. "Cell culture meat" has become the capital and popular technology highly concerned by the world's major investment banks.

Based on the product design and development principles of "serum substitution, clean production, and consistent performance", Angel Yeast Co., Ltd. introduced the CM series of yeast extract for cell culture, which uses high-quality yeast extract as the core raw material and is rich in amino acids necessary for vitro culture, as well as rich in active peptides, appropriate carbohydrates, growth factors, etc. It can be used as synergists and supplements for cell nutrition, and have outstanding performance such as improving cell vitality, promoting cell proliferation, and increasing the yield of target products. In addition, CM series products for cell culture enriched the nutritional components through the consumption of different types of cells and screened out significant influencing factors. The key nutritional components for the vitro expansion of serum were identified. As the serum substitutes in independent customized formula design and based on the features "safe, clean, stable, and efficient" Angel CM series of yeast extract are gradually used in mainstream cell lines (mammalian cells such as hamster cells CHO-K1, CHO-S, CHO- DXB11, BHK, human cells HEK293, CAP and mouse cells NS0, Sp2 / 0; insect cells and plant cells) .


Published by Yin Qiang

Senior manager of Angel Yeast APAC Division

About Angel Microbial Nutrition

Angel YE, rich in protein, amino acids, peptides, nucleotides, B vitamins and trace elements. With the advantages of having no allergic source and being non-transgenic, high efficiency and stable quality, Angel YE are widely applied in the biological laboratories and industrial-scale fermentation, promoting the product safety and technical progress in the global fermentation industry.

About Angel:

Angel Yeast Company is a high-tech listed company specializing in yeast and biotech. Product business covers Yeast and Baking, Yeast Extract-Savoury, Nutrition & Health and Biotechnology fields. It is one of the world's leading companies in the yeast industry. Angel has 12 holding subsidiaries and provides products and services for more than 150 countries and regions.


Press contact:


Address: 168 Chengdong Avenue, Yichang, Hubei 443003, P. R.China

Tel: +86-717-6369227

Fax: +86-717-6368757

email: aie@angelyeast.com

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