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Application of GroPro Aqua in low fish meal diets for olive flounder

April 21st, 2020

By Xiangqian Xiao

In recent years, the application of GroPro Aqua in aquatic products has attracted more and more attention, and also attracted the interest of researchers. Recently, the latest research results on GroPro Aqua were included in the SCI journal ‘Aquaculture’ with an impact factor of 3.02 on April 6, 2020. This study tested the application of seven functional additives in low meal diet of olive flounder. GroPro Aqua is called yeast extract nucleotides(YEN)in this paper. The results showed that YEN (GroPro Aqua), GAB (gamma-aminobutyric acid) and SGS (song-gang stone) could be the most effective functional additives in the low fish meal diet of olive flounder.


Olive flounder is the most cultured fish in Korea, which has high economic value in the whole East Asia. As a cold, warm, benthic and carnivorous fish, the commercial diet of olive flounder usually includes 50-70% fish meal. In addition, there are higher requirements for protein demand and quality in feed for olive flounder. It has been reported that using plant protein instead of fish meal can reduce the growth and feed utilization of olive flounder. The purpose of this study was to evaluate the effects of seven additives in low fish meal diet on the growth and immune performance of olive flounder. In this study, the initial weight of olive flounder was 5.26 ± 0.17g, the dosage of fish meal in the control group (low fish meal group) was 45.5% (Table 1), and the dosage of GroPro Aqua was 4kg/T by replacing the same amount of flour.


Brief introduction of research results:

Improves production performance

Under the same feeding amount, GroPro Aqua can significantly improve the weight gain rate, specific growth rate, feed and protein efficiency of olive flounder. GroPro Aqua is YEN in Table 4.


Improve intestinal structure and function

GroPro Aqua is rich in nucleic acids, which can promote the growth of intestinal microvilli, increase the length of intestinal microvilli, increase the absorption surface area of nutrients. At the same time, GroPro Aqua can improve the trypsin activity and the ability of protein digestion and absorption. GroPro Aqua is E in Fig. 1 and is YEN in Table 8, Table 9.




Enhance immunity and disease resistance

The β-glucan and nucleic acid contained in GroPro Aqua can improve the non-specific immunity of fish and regulate the expression level of Hsp70.

In terms of non-specific immune related indexes, GroPro Aqua significantly improved the indexes of SOD enzyme, myeloperoxidase activity and neutrophil bactericidal function. GroPro Aqua is YEN in Table 7.


HSP-70 gene is related to stress resistance. When subjected to certain environmental stress, HSP-70 is induced to express, participate in stress protection, and improve the tolerance to environmental stress or injury. GroPro Aqua is YEN in Fig. 2.


GroPro Aqua improved the cumulative survival rate after challenged with Edwardsiella tarda, and enhanced the resistance to disease. GroPro Aqua is YEN in Fig. 3.


Above all, the publication of this paper further confirmed the function and role of GroPro Aqua as a protein raw material in aquaculture, and provided a basis for the application of GroPro Aqua in the diet with low fish meal of olive flounder.


About Angel Animal Nutrition:

Fubon is a brand of Angel Animal Nutrition. Fubon is committed to developing natural, efficient microbial feed derived from yeast with Angel's leading technology in yeast industry, providing the best service solutions for the nutrition and health in animals. Angel Animal Nutrition creates value for global feed and animal agriculture customers through continuously upgraded products and professional services.

About Angel:

Angel Yeast Company is a high-tech listed company specializing in yeast and biotech. Product business covers Yeast and Baking, Yeast Extract-Savoury, Nutrition & Health and Biotechnology fields. It is one of the world's leading companies in the yeast industry. Angel has 12 holding subsidiaries and provides products and services for more than 150 countries and regions.


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Address: 168 Chengdong Avenue, Yichang, Hubei 443003, P. R.China

Tel:+86-717-6369520, 6369558


email: aie@angelyeast.com

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