May 9th, 2020
by Xiangqian Xiao
Since the first SCI paper of YeaSense was published, another YeaSense's paper in aquaculture was recently included in the SCI journal Veterinary Medicine and Science, which means that yeast products have made a breakthrough again in antibiotic replacement.
The results show that YeaSense is an effective alternative for antibiotics, which provides a new way to solve the problems of antibiotic residue and resistance in aquaculture.
YeaSense is called "yeast glycoprotein (YG)" in the paper.
Brief introduction of research results:
1. In vitro bacteriostatic test
The results showed that Aeromonas caviae was only sensitive to ceftazidime (41mm), cefotaxime (36mm), vancomycin (13mm), furantoin (29mm), aztreonam (42mm), rifampicin (28mm) and amikacin (25mm), among which the bacteriostatic circle of YG (YeaSense) was 25mm.
2. MIC and MBC
The mic and MBC of YeaSense to Aeromonas caviae were 83. 3mg/ml and 166. 7mg/ml, respectively.
3. Intestinal flora test
The results showed that the intestinal flora of each experimental group and the control group were mainly of the Cetacea genus. Compared with the control group, Aeromonas caviae became the predominant intestinal bacteria. Compared with the antibiotic group (rifampicin 200mg/kg), the Aeromonas abundance in the treatment group (YeaSense 800mg/kg) was significantly lower (P<0.05). Meanwhile, diversity and abundance of erysipeliaceae and porphyromonaceae in YG group were the highest among the four groups. (Note: Aeromonas caviae are mostly aquatic conditional pathogens) the results showed that compared with rifampin, adding YeaSense could significantly reduce the abundance of aquatic conditional pathogens Aeromonas caviae and increase the diversity of intestinal microorganisms.
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