In a landmark collaboration between Angel Yeast and Cryptobiotix SA, researchers have published a pioneering study in Frontiers in Microbiology demonstrating how yeast protein (YP)—a sustainable, non-animal protein source—can significantly promote healthy aging by reshaping the gut microbiome.

Key Findings:

· Microbiome and Metabolome Benefits: The study, utilizing advanced ex vivo SIFR® technology, compared YP with whey protein isolate (WPI) and soy protein isolate (SPI) in adults aged 50–65. Results showed YP enhanced gut barrier integrity, reduced inflammation (via lower pro-inflammatory markers and elevated IL-10), and boosted microbial diversity—a critical factor linked to longevity.

· Unique Advantages of YP: YP outperformed competitors by restoring butyrate-producing bacteria, producing fewer gas emissions (indicating superior digestive tolerability), and yielding the lowest levels of trimethylamine N-oxide (TMAO), a compound associated with age-related mortality.

· Metabolomic Insights: Untargeted metabolomics revealed YP’s ability to generate beneficial amino acid-derived metabolites, such as indoles and polyamines, which support health span through gut-organ axes.

As global demand for eco-friendly protein alternatives surges, YP emerges as a hypoallergenic, vegan-friendly option with dual benefits: reducing reliance on animal-based proteins while actively improving gut health.

“Our findings position yeast protein as a transformative ingredient for aging populations,” said Dr. Yan Zhang of Angel Yeast. “Beyond nutrition, YP actively modulates the microbiome to combat age-related decline, offering a holistic approach to healthy aging.”

Dr. Jonas Poppe of Cryptobiotix added, “This collaboration bridges cutting-edge biotechnology with practical dietary solutions, highlighting the power of international scientific partnerships.”

Full study details and implications for dietary guidelines will be released in the coming weeks.

About the Partners:

• Angel Yeast: A global leader in yeast and fermentation technologies, driving innovation in sustainable food and health solutions.

• Cryptobiotix SA: A biotech firm specializing in microbiome research and technology, enabling precise analysis of gut-health interactions

Note: The study, titled "Yeast Protein Modulates Gut Microbiome and Metabolome to Promote Healthy Aging," is available via Frontiers in Microbiology (DOI: 10.3389/fmicb.2025.1697734).

About Angel Human Health：

Specialized in yeast and fermentation, AHH is committed to developing innovative, differentiated, science-based functional ingredients and customized solutions, to help our customers get enduring success, as well as contribute to a healthier and sustainable world together.

About Angel:

Angel Yeast Company is a high-tech listed company specializing in yeast and biotech. Product business covers Yeast and Baking, Yeast Extract-Savoury, Nutrition & Health and Biotechnology fields. It is one of the world's leading companies in the yeast industry. Angel has 12 holding subsidiaries and provides products and services for more than 150 countries and regions.

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